Post-burn sacrquality whenapplying allogeneic platelet lysate versus 1% silver sulfadeazine

Abstract

Introduction: Burns are traumatic injuries capable of leading to death or leaving disabling or deforming sequelae, which has motivated the search for new alternative treatments aimed at tissue regeneration, such as the use of platelet lysate.

 Objetive: The quality of the resulting scar was evaluated after the application of allogeneic platelet lysate versus 1% silver sulfadiazine in deep second-degree burns caused by boiling water, in the Plastic Surgery and Burn Unit of General Hospital Dr. Juan Bruno Zayas Alfonso in Santiago de Cuba from October 2020 to October 2021. Method: A quasi-experimental study was carried out, where patients were randomly assigned to two treatment groups of 30 each: the first was given platelet lysate and the second 1% silver sulfadiazine. Percentages and totals were calculated as summary measures for the variables, and t-student and Chi-square statistical tests were applied, determining their level of significance.

 Results: The application of allogeneic platelet lysate accelerated tissue regeneration, made it possible to reduce the healing time of burns, with 66.7% of patients healed before 13 days. A resulting scar of better quality was obtained compared to 1% silver sulfadiazine.

 Conclusions: These results indicate that the use of allogeneic platelet lysate, under these study conditions, is ideal and could become a potential bioproduct for promoting tissue regeneration and obtaining a satisfactory quality scar.