Review of Tissue Engineering as a Regenerative Therapy Applied to Plastic Surgery
Keywords:
stem cells; growth factors; scaffolds; regenerative therapy; tissue engineering; plastic surgeryAbstract
Introduction: Tissue engineering is an emerging discipline that combines principles of cellular biology, biomedical engineering and materials science with the aim of developing innovative therapeutic solutions for the regeneration, repair and replacement of damaged tissues. Through the use of biomaterials, stem cells and bioactive factors, it offers new possibilities in the treatment of degenerative diseases, traumatic injuries and congenital defects.
Objective: To show the regenerative therapy options based on tissue engineering for application in plastic surgery and caumatology.
Methods: Bibliographic review in Pubmed, Elsevier, Google Scholar, Research and Scielo; articles in English and Spanish.
Results: From the 115 sources found, 39 were selected taking into account as inclusion criteria full, original articles, bibliographic reviews, meta-analyses, clinical trials and case presentations from 1979 to 2024. 76 that did not meet the selection criteria were excluded.
Conclusions: Tissue engineering is a field in regenerative medicine still unexploited in Cuba and with great potential for applications in the specialty of plastic surgery. It is up to specialists to deepen their knowledge on the subject in order to access a higher level of restorative, safe and minimally invasive treatment that translates into quality of life for patients.
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1. Zhang J, Xu W, Li C, Meng F, Guan Y, Liu X, et al. Tissue Engineering Microtissue: Construction, Optimization, and Application. Tissue Eng Part B Rev. 2022;28(2):393-404. DOI: https://doi.org/10.1089/ten.TEB.2020.0370
2. Langer R, Vacanti J. Advances in tissue engineering. J Pediatr Surg. 2016;51(1):8-12. DOI: https://doi.org/10.1016/j.jpedsurg.2015.10.022
3. Donderwinkel I, Tuan RS, Cameron NR, Frith JE. Tendon tissue engineering: Current progress towards an optimized tenogenic differentiation protocol for human stem cells. Acta Biomater. 2022;145:25-42. DOI: https://doi.org/10.1016/j.actbio.2022.04.028
4. Ahmed HM, Moreira Teixeira LS. New Endeavors of (Micro)Tissue Engineering: Cells Tissues Organs on-Chip and Communication Thereof. Cells Tissues Organs. 2022;211(6):721-35. DOI: https://doi.org/10.1159/000516356
5. Shyngys M, Ren J, Liang X, Miao J, Blocki A. Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine. Front Bioeng Biotechnol. 2021;9:603608. DOI: https://doi.org/10.3389/fbioe.2021.603608
6. Escobar Vega H, Zaldain Ramos D, Morales Novo L, Tamayo Carbon D, Exposito Jalturin A. Aplicaciones del plasma rico en plaquetas en cirugía estética: revisión de la literatura. Acta Médica. 2020 [acceso 24/9/2024];21(2). Disponible en: https://revactamedica.sld.cu/index.php/act/article/view/101
7. Tamayo Carbón A, Cuastumal Figueroa D. Introducción del nanofat para la terapia regenerativa en Cirugía Plástica y Caumatología. Acta Médica. 2022 [acceso 24/9/2024];23(3). Disponible en: https://revactamedica.sld.cu/index.php/act/article/view/313
8. Muñiz Vigueras JC, Tamayo Carbón AM, Borroto Martínez K, Vera Shelton S. Cierre de heridas crónicas con el uso de membrana amniótica. Invest Medicoquir. 2023 [acceso 24/9/2024];15. Disponible en: https://revcimeq.sld.cu/index.php/imq/article/view/831
9. Green H, Kehinde O, Thomas J. Growth of cultured human epidermal cells into multiple epithelia suitable for grafting. Proc Natl Acad Sci USA. 1979;76(11):5665-8. DOI: https://doi.org/10.1073/pnas.76.11.5665
10. Yannas IV, Burke JF, Orgill DP, Skrabut EM. Wound tissue can utilize a polymeric template to synthesize a functional extension of skin. Science. 1982;215(4529):174-6. DOI: https://doi.org/10.1126/science.7031899
11. Bell E, Paul Ehrlich H, Buttle D, Nakatsuji T. Tejido vivo formado in vitro y aceptado como tejido equivalente a la piel de espesor completo. Science. 1981;211:1052-4. DOI: https://doi.org/10.1126/science.7008197
12. Berthiaume F, Maguire TJ, Yarmush ML. Tissue engineering and regenerative medicine: history, progress, and challenges. Annu Rev Chem Biomol Eng. 2011;2:403-30. DOI: https://doi.org/10.1146/annurev-chembioeng-061010-114257
13. Sahakyants T, Vacanti JP. Tissue engineering: from the bedside to the bench and back to the bedside. Pediatr Surg Int. 2020;36(10):1123-33. DOI: https://doi.org/10.1007/s00383-020-04722-z
14. De Assis ACC, Reis ALS, Nunes LV, Ferreira LFR, Bilal M. Stem Cells and Tissue Engineering-Based Therapeutic Interventions: Promising Strategies to Improve Peripheral Nerve Regeneration. Cell Mol Neurobiol. 2023;43(2):433-54. DOI: https://doi.org/10.1007/s10571-022-01199-3
15. Liu C, Pei M, Li Q, Zhang Y. Decellularized extracellular matrix mediates tissue construction and regeneration. Front Med. 2022;16(1):56-82. DOI: https://doi.org/10.1007/s11684-021-0900-3
16. Goessler UR, Hormann K, Riedel F. Tissue engineering with adult stem cells in reconstructive surgery (review). Int J Mol Med. 2005;15(6):899-905. PMID: 15870891.
17. Biniazan F, Stoian A, Haykal S. Adipose-Derived Stem Cells: Angiogenetic Potential and Utility in Tissue Engineering. Int J Mol Sci. 2024;25(4):2356. DOI: https://doi.org/10.3390/ijms25042356
18. Yang R, Yang S, Zhao J, Hu X, Chen X, Wang J, et al. Progress in studies of epidermal stem cells and their application in skin tissue engineering. Stem Cell Res Ther. 2020;11(1):303. DOI: https://doi.org/10.1186/s13287-020-01796-3
19. Cosgriff Hernandez E, Timmins LH. Model-Directed Design of Tissue Engineering Scaffolds. ACS Biomater Sci Eng. 2022;8(11):4622-4. DOI: https://doi.org/10.1021/acsbiomaterials.1c01386
20. Flores Jiménez MS, Garcia Gonzalez A, Fuentes Aguilar RQ. Review on Porous Scaffolds Generation Process: A Tissue Engineering Approach. ACS Appl Bio Mater. 2023;6(1):1-23. DOI: https://doi.org/10.1021/acsabm.2c00740
21. Ramzan F, Salim A, Khan I. Osteochondral Tissue Engineering Dilemma: Scaffolding Trends in Regenerative Medicine. Stem Cell Rev Rep. 2023;19(6):1615-34. DOI: https://doi.org/10.1007/s12015-023-10545-x
22. Lau TT, Wang DA. Bioresponsive hydrogel scaffolding systems for 3D constructions in tissue engineering and regenerative medicine. Nanomedicine (Lond). 2013;8(4):655-68. DOI: 10.2217/nnm.13.32. PMID: 23560414
23. Eldeeb AE, Salah S, Elkasabgy NA. Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review. AAPS PharmSciTech. 2022;23(7):267. DOI: https://doi.org/10.1208/s12249-022-02419-1
24. Laird NZ, Acri TM, Chakka JL, Quarterman JC, Malkawi WI, Elangovan S, et al. Applications of nanotechnology in 3D printed tissue engineering scaffolds. Eur J Pharm Biopharm. 2021 Apr;161:15-28. DOI: https://doi.org/10.1016/j.ejpb.2021.01.018
25. Zhang S, Lin A, Tao Z, Fu Y, Xiao L, Ruan G, et al. Microsphere-containing Hydrogel Scaffolds for Tissue Engineering. Chem Asian J. 2022;17(20):e202200630. DOI: https://doi.org/10.1002/asia.202200630
26. Kohestani AA, Xu Z, Baştan FE, Boccaccini AR, Pishbin F. Electrically conductive coatings in tissue engineering. Acta Biomater. 2024;186:30-62. DOI: https://doi.org/10.1016/j.actbio.2024.08.007
27. Xue W, Du J, Li Q, Wang Y, Lu Y, Fan J, et al. Preparation, Properties, and Application of Graphene-Based Materials in Tissue Engineering Scaffolds. Tissue Eng Part B Rev. 2022;28(5):1121-36. DOI: https://doi.org/10.1089/ten.TEB.2021.0127
28. Moghaddam AS, Khonakdar HA, Arjmand M, Jafari SH, Bagher Z, Moghaddam ZS, et al. Review of Bioprinting in Regenerative Medicine: Naturally Derived Bioinks and Stem Cells. ACS Appl Bio Mater. 2021;4(5):4049-70. DOI: https://doi.org/10.1021/acsabm.1c00219
29. Morales Navarro D. Ingeniería tisular como puntal de la medicina regenerativa en estomatología. Rev Cubana Estomatol. 2014 [acceso 24/09/2024];51(3):288-304. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75072014000300006&lng=es
30. Díaz García AM, Felipe Gómez AM. Las investigaciones en el área de la bionanotecnología en Cuba. Mundo nano. 2017;10(19):37-71. DOI: https://doi.org/10.22201/ceiich.24485691e.2017.19.62392
31. Camacho Assef JA, Camacho Escalante L, Gómez Mantilla N, Camacho Assef V, López Borroto K, García Garriga. Desarrollo de la medicina regenerativa en Cuba. Mediciego. 2017 [acceso 25/09/2024];23(4). Disponible en: https://www.medigraphic.com/pdfs/mediciego/mdc-2017/mdc174i.pdf
32. Tamayo Carbón A. Nanofat, su expansión en la asistencia médica. Acta Médica. 2024 [acceso 25/09/2024];25. Disponible en: https://revactamedica.sld.cu/index.php/act/article/view/537
33. León de Ulloa J, López Cruz A, González Ruíz JE, Pérez Rodríguez YV, Ríos Moreno R. Diseño de andamios personalizados para la regeneración de una mandíbula con dimensiones reducidas. Rev Cubana Invest Bioméd. 2017 [acceso 25/09/2024];36(1):1-8. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-03002017000100001&lng=es
34. González González A, Lugo Hernández R, Zambrano Robledo PdC, Rivas Santana M, Risco A, Pérez Rodríguez R. Caracterización de la permeabilidad de andamios porosos de ácido poli-láctico fabricados con impresoras 3D comerciales. Ingeniería Mecánica. 2023 [acceso 25/09/2024];26(2):30-9. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1815-59442023000200030&lng=en&tlng=
35. González González A, Rivas Santana M, Zambrano Robledo PdC. Thermal and morphological characterization of 3D-printed PLA scaffolds for biomedical applications. MRS Advances. 2022;7:1206-11. DOI: https://doi.org/10.1557/s43580-022-00454-5
36. González González A, Rivas Santana M, Zambrano Robledo PdC Modelling and optimization of compressive strength of 3D printed PLA scaffolds for biomedical applications. MRS Advances. 2022;7:1212-7. DOI: https://doi.org/10.1557/s43580-022-00455-4
37. Gao W, Wang C, Li Q, Zhang X, Yuan J, Li D, et al. Application of medical imaging methods and artificial intelligence in tissue engineering and organ-on-a-chip. Front Bioeng Biotechnol. 2022;10:985692. DOI: https://doi.org/10.3389/fbioe.2022.985692
38. Khayambashi P, Iyer J, Pillai S, Upadhyay A, Zhang Y, Tran SD. Hydrogel Encapsulation of Mesenchymal Stem Cells and Their Derived Exosomes for Tissue Engineering. Int J Mol Sci. 2021;22(2):684. DOI: https://doi.org/10.3390/ijms22020684
39. Hade MD, Suire CN, Suo Z. Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine. Cells. 2021;10(8):1959. DOI: https://doi.org/10.3390/cells10081959
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Copyright (c) 2025 Diana Katherine Cuastumal Figueroa
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